Entente Saint Clément Montferrier, who play in the R1 division, will host Stade Rennais F.C. in the last 16 of the Coupe Gambardella on Sunday 25 February.
ESCM's U18s previously eliminated Rodez Aveyron (1-0), Olympique Rovenain (2-2; 3-4 on penalties) and Andrézieux-Bouthéon (0-0; 4-2 on penalties).